Estrovis 4000
Estrovis 4000 - General Information
The 3-cyclopentyl ether of ethinyl estradiol.
Pharmacology of Estrovis 4000
Estrovis 4000 is the 3-cyclopentyl ether of ethinyl estradiol (the active metabolite). After gastrointestinal absorption, it is stored in adipose tissue where it is slowly released and metabolized principally to the parent compound, ethinyl estradiol. Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol.
Additional information about Estrovis 4000
Estrovis 4000 Indication: Used in hormone replacement therapy, treating symptoms of menopause such as hot flashes. Also used to treat breast and prostate cancer.
Mechanism Of Action: Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Quinestrol
Synonyms: Quinestrolo [dcit]; Quinestrolum [inn-latin]; Estradiol-17-beta 3-cyclopentyl ether; 17-alpha-Ethinylestradiol 3-cyclopentyl ether; 17alpha-Ethynylestradiol 3-cyclopentyl ether
Drug Category: Hormone Replacement Agents; Estrogens
Drug Type: Small Molecule; Approved
Other Brand Names containing Quinestrol: Estrovis; Plestrovis; Qui-lea; Estrovister; Estrovis 4000; Eston;
Absorption: Absorbed following oral administration.
Toxicity (Overdose): Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females.
Protein Binding: Not Available
Biotransformation: Metabolized principally to the parent compound, ethinyl estradiol. Ethinyl estradiol is metabolized in the liver. Quantitatively, the major metabolic pathway for ethinyl estradiol, both in rats and in humans, is aromatic hydroxylation, as it is for the natural estrogens.
Half Life: Not Available
Dosage Forms of Estrovis 4000: Tablet Oral
Chemical IUPAC Name: (8R,9S,13S,14S,17R)-3-cyclopentyloxy-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol
Chemical Formula: C25H32O2
Quinestrol on Wikipedia: https://en.wikipedia.org/wiki/Quinestrol
Organisms Affected: Humans and other mammals
